鏈卞仴搴

涓汉绠浠

鏈卞仴搴凤紝鐢凤紝1967骞寸敓锛屽畨寰界渷闃滃崡鍘夸汉銆傚浗闄呰憲鍚嶆鐗╃敓鐗╁瀹躲佹鐗╂姉閫嗗垎瀛愮敓鐗╁棰嗗啗绉戝瀹讹紝缇庡浗绉戝闄㈤櫌澹紝鐜颁换涓闄笂娴锋鐗╅嗗鐢熺墿瀛︾爺绌朵腑蹇冧富浠汇傚湪妞嶇墿鎶楁棻銆佽愮洂涓庤愪綆娓╂柟闈㈠仛鍑轰簡鏉板嚭閫犺锛屾槸涓栫晫妞嶇墿绉戝棰嗗煙鍙戣〃璁烘枃寮曠敤鐜囨渶楂樼殑绉戝瀹朵箣涓銆 

杩戝勾鏉ュ紩棰嗘鐗╁熀鍥犵紪杈戝绉戠殑鍙戝睍锛屽鎷熷崡鑺ュ拰姘寸ɑ鍩哄洜缂栬緫鎶鏈殑鐮旂┒绯荤粺娣卞叆銆備互姘寸ɑ涓虹爺绌堕噸鐐癸紝杩涜浜嗗叏鏂逛綅鐨勫熀鍥犵紪杈戞妧鏈殑鏇存柊鍜屽畬鍠勶紝浠嶤RISPR/Cas9鐨勫叏鍩哄洜缁勭殑off-target娴嬭瘯銆佸埄鐢ㄥ弻鐢熺梾姣掑疄鐜癏R浠嬪鐨勫熀鍥犳浛鎹㈠拰瀹氱偣鎻掑叆銆丆pf1绛夊悇鍨嬪伐鍏风殑娴嬭瘯搴旂敤銆佸崟纰卞熀缂栬緫鎶鏈綋绯荤瓑鍚勬柟闈㈣儨鍒╃郴缁熷湴鎼缓璧蜂簡鏈夋晥鐨勬按绋诲熀鍥犵紪杈戞妧鏈綋绯汇傜浉鍏崇爺绌剁粨鏋滃彂琛ㄥ湪PNAS銆丮olecular Plant鍜孭lant Biotechnology Journal銆 

 

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